|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Aquaporin 1 and 3 were upregulated in cervical cancer compared to mild cervicitis and CIN2-3 (P<0.05); Tumor expression of aquaporin 1, 3 significantly increased in advanced stage disease, and patients with deeper tumor infiltration, lymph node metastases or larger tumor volume (P<0.05).
|
24918928 |
2014 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Aquaporin-1 (AQP1) is a water channel protein expressed in vascular endothelia and involved in impaired angiogenesis in tumors.
|
17273788 |
2007 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Correlation of expression pattern of aquaporin-1 in primary central nervous system tumors with tumor type, grade, proliferation, microvessel density, contrast-enhancement and perilesional edema.
|
23361277 |
2013 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Aquaporin-1 (AQP1) is a glycoprotein that mediates osmotic water transport, its expression has been found to correlate with tumour stage in some tumours.
|
22415096 |
2012 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Renal tumour subtype/nephron segment-specific gene expression detected by RQ-PCR demonstrated that the tumour expressed relatively high amounts of alpha-methylacyl-CoA racemase (AMACR) and the KIT oncogene, but relatively low amounts of carbonic anhydrase IX (CA9), aquaporin 1 (AQP1), claudin 7 (CLDN7), parvalbumin (PVALB), chloride channel Kb (CLCNKB) and 11-beta-hydroxysteroid dehydrogenase 2 (HSD11B2), suggesting diverse mRNA signatures.
|
17323425 |
2007 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In contrast, aquaporin-1, possibly aquaporins-3 and -5, and GLUT-3 message appeared upregulated in the tumors.
|
11161003 |
2001 |
|
Tumor Cell Invasion
|
0.070 |
AlteredExpression
|
phenotype |
BEFREE |
AQP-1 levels were modulated in LEC using retroviral overexpression or small interfering RNA (siRNA) knockdown and functional effects on invasion, membrane blebbing dynamics, and osmotic water permeability were assayed.
|
20578142 |
2010 |
|
Tumor Cell Invasion
|
0.070 |
AlteredExpression
|
phenotype |
BEFREE |
We find that migrating lead cranial neural crest cells express AQP-1 mRNA and protein, implicating a biological role for water channel protein function during invasion.
|
31826865 |
2020 |
|
Tumor Cell Invasion
|
0.070 |
AlteredExpression
|
phenotype |
BEFREE |
The present study aimed to assess the expression and functional role of aquaporin-1 (AQP1) in glioblastoma multiforme (GBM) migration, invasion and vasculogenic mimicry (VM).
|
29257313 |
2018 |
|
Malignant Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
Aquaporin-1 (AQP1) has been proposed as a dual water and cation channel that when upregulated in cancers enhances cell migration rates; however, the mechanism remains unknown.
|
31477744 |
2019 |
|
Malignant Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
Expression of aquaporin-1 (AQP1) in endothelial cells is critical for their migration and angiogenesis in cancer.
|
29495367 |
2018 |
|
Malignant Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
A possible candidate-gene for such variation is Aquaporin-1 (AQP1), since Aquaporin-1-expression influences the pathogenesis and outcome of various malignancies.
|
24014128 |
2013 |
|
Cholestasis
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Adenovirus-mediated human aquaporin-1 expression in hepatocytes improves lipopolysaccharide-induced cholestasis.
|
29087027 |
2017 |
|
Cholestasis
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Improved hepatic MRP2/ABCC2 transport activity in LPS-induced cholestasis by aquaporin-1 gene transfer.
|
31377196 |
2019 |
|
melanoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
In a previous study aquaporin 1 (AQP1) protein expression was found to be associated with increased mortality and decreased progression free survival in cutaneous melanoma.
|
30378011 |
2018 |
|
melanoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Aquaporin 1 protein expression is associated with BRAF V600 mutation and adverse prognosis in cutaneous melanoma.
|
26848795 |
2016 |
|
Neoplasm Metastasis
|
0.040 |
AlteredExpression
|
phenotype |
BEFREE |
Water channel aquaporin-1 (AQP1) enhances water flux across cell membranes, which is highly expressed and associated with cell migration, metastasis and angiogenesis in some human cancers.
|
31251110 |
2019 |
|
Malignant Pleural Mesothelioma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
The aim of this study was to evaluate the expression of AQP-1 and its prognostic value in a series of pleural MM effusions, from a geographical area with high concentrations of fluoro-edenite (FE).
|
29873855 |
2018 |
|
Malignant Pleural Mesothelioma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Gene expression profile of aquaporin 1 and associated interactors in malignant pleural mesothelioma.
|
23313295 |
2013 |
|
Malignant Pleural Mesothelioma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
The immunohistochemical expression of aquaporin-1 (AQP1) in asbestos-related malignant pleural mesothelioma (MPM) is emerging as a useful prognostic indicator of improved survival.
|
29495596 |
2018 |
|
Malignant tumor of colon
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Aquaporin-1 activity of plasma membrane affects HT20 colon cancer cell migration.
|
19787701 |
2009 |
|
Septicemia
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Leukocyte aquaporin-1 expression was induced at the onset of sepsis (median 1.71-fold increase; interquartile range: 0.99 to 2.42, P = 0.012 from baseline) and was further increased upon septic shock (median 3.00-fold increase; interquartile range: 1.20 to 5.40, P = 0.023 from sepsis, Wilcoxon signed-rank test); no difference was observed between baseline and discharge in patients who did not develop sepsis.
|
24028651 |
2013 |
|
Sepsis
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Leukocyte aquaporin-1 expression was induced at the onset of sepsis (median 1.71-fold increase; interquartile range: 0.99 to 2.42, P = 0.012 from baseline) and was further increased upon septic shock (median 3.00-fold increase; interquartile range: 1.20 to 5.40, P = 0.023 from sepsis, Wilcoxon signed-rank test); no difference was observed between baseline and discharge in patients who did not develop sepsis.
|
24028651 |
2013 |
|
Cervix carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Significance and expression of aquaporin 1, 3, 8 in cervical carcinoma in Xinjiang Uygur women of China.
|
22901156 |
2012 |
|
Cervix carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Decreased expression of aquaporin 1 correlates with clinicopathological features of patients with cervical cancer.
|
31118662 |
2019 |